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008			240626s2019 xxka gob 001 0 eng
020			_a9780191847929 _cGBP245.81 _q(e-book.)
024	7		_2DOI: _ahttps://doi.org/10.1093/oso/9780198810681.001.0001
040			_beng _cIN-MiVU
082	0	4	_221 _a612.1111 _bSTO/H
100	1		_aStorz, Jay F., _eauthor
245	1	0	_aHemoglobin: _bInsights into protein structure, function, and evolution / _c by Jay F. Storz, _h[electronic resource]
250			_aFirst edition.
260	3		_aOxford, United Kingdom : _bOxford University Press, _c2019.
300			_ae-book contains 237 pages
504			_aIncludes bibliographical references and index.
505	0		_aContents Front Matter Copyright Page Dedication Preface Expand1 Principles of protein structure View chapter Expand2 A study in scarlet: The role of hemoglobin in blood gas transport View chapter Expand3 Allosteric theory View chapter Expand4 Hemoglobin structure and allosteric mechanism View chapter Expand5 Evolution of the vertebrate globin gene family View chapter Expand6 Gene duplication and hemoglobin isoform differentiation View chapter Expand7 The evolution of novel hemoglobin functions and physiological innovation View chapter Expand8 Biochemical adaptation to environmental hypoxia View chapter Expand9 Darwin’s molecule: Evolutionary insights into mechanisms of biochemical adaptation and protein evolution View chapter End Matter Index Plates
520	3		_aAbstract The aims of this book are to provide a synthesis of our current understanding of hemoglobin structure, function, and evolution, and to illustrate how research on this paradigmatic protein has provided general insights into mechanisms of molecular evolution and biochemical adaptation. The book promotes an appreciation of how mechanistic insights into protein function can enrich our understanding of how evolution works and, reciprocally, it highlights how approaches in evolutionary genetics (such as phylogenetic comparative methods and ancestral sequence reconstruction) can be brought to bear on questions about the functional evolution of proteins. This treatise on the functional evolution of hemoglobin illustrates how research on a single, well-chosen model system can enhance our investigative acuity and bring key conceptual questions into sharp focus. Hemoglobin: Insights into Protein Structure, Function, and Evolution is suitable for a wide range of graduate level students taking interdisciplinary courses in biochemical physiology and protein evolution, and will serve as a key reference for researchers in molecular evolution, biochemistry, and comparative physiology.
650		0	_aHemoglobin.
653	0	0	_aBiochemistry,
653	0	0	_aGenetics and Genomics,
653	0	0	_aMolecular and Cell Biology,
653	0	0	_aEvolutionary Biology.
856	4	7	_3https://academic.oup.com/book/27178 _uhttps://academic.oup.com/book/27178 _yClick here
942			_2ddc _cEB