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| 008 | 240626s2019 xxka gob 001 0 eng d | ||
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_a9780191869266 _cGBP258.75 _q(e-book) |
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| 024 | 7 |
_2DOI: _ahttps://doi.org/10.1093/oso/9780198831204.001.0001 |
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_beng _cIN-MiVU |
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| 082 | 0 | 4 |
_221 _a572.865 _bLUC/E |
| 100 | 1 |
_aLucchesi, J. C. _eauthor _q(John C.) |
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| 245 | 1 | 0 |
_aEpigenetics, nuclear organization and gene function : _bWith implications of epigenetic regulation and genetic architecture for human development and health / _cby John C. Lucchesi. _h[electronic resource] |
| 250 | _aFirst edition. | ||
| 260 | 3 |
_aOxford, United Kingdom : _bOxford University Press, _c2019. |
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| 300 | _ae-book contains 286 pages; | ||
| 504 | _aIncludes bibliographical references and index. | ||
| 505 | 0 | _aContents Front Matter Copyright Page Dedication and Acknowledgments About the Author Preface Part I An Introduction to Epigenetics and Epigenetic Regulation John C. Lucchesi Expand1 Epigenetic phenomena in fungi, plants and animals View chapter Expand2 The basic structure of chromatin View chapter Expand3 The basic mechanism of gene transcription View chapter Part II Transcription is Regulated by Epigenetic Mechanisms John C. Lucchesi Expand4 Chromatin modification and remodeling View chapter Expand5 Epigenetic chromatin changes and the transcription cycle View chapter Expand6 The role of non-coding RNAs View chapter Expand7 Maintenance of the active and inactive states View chapter Expand8 DNA methylation and gene expression View chapter Expand9 Regulation of domains and whole chromosomes View chapter Part III The Interplay Between Transcription and Nuclear Structures John C. Lucchesi View part front matter Expand10 Architectural organization of the genome View chapter Expand11 The nuclear envelope View chapter Expand12 The nucleolus View chapter Expand13 Nuclear bodies View chapter Part IV Inheritance of Chromatin Structure and Functional States John C. Lucchesi Expand14 Chromatin replication View chapter Expand15 DNA repair and genomic stability View chapter Expand16 Inheritance of chromatin modifications through the cell cycle View chapter Expand17 Stem cells View chapter Expand18 Nuclear reprogramming and induced pluripotency View chapter Expand19 Transgenerational inheritance of epigenetic traits View chapter Part V Epigenetics, Human Health and Development John C. Lucchesi View part front matter Expand20 Aging, cellular senescence and cancer: the role of genomic instability, cellular homeostasis and telomeres View chapter Expand21 Aging, cellular senescence and cancer: epigenetic alterations and nuclear remodeling View chapter Expand22 Developmental systems and their dysfunction View chapter End Matter Index | |
| 520 | 3 | _aAbstract Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. Epigenetic changes, consisting principally of DNA methylation, histone modifications and non-coding RNAs, maintain and modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. This book’s primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and its interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin) and its distribution within a functionally compartmentalized nucleus. Dysfunctions at any level of genetic regulation have the potential to result in an increased susceptibility to disease or actually give rise to overt pathologies. As illustrated in this book, research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. | |
| 650 | 0 | _aEpigenetics. | |
| 650 | 0 | _aGenetic regulation. | |
| 650 | 2 | _aEpigenomics. | |
| 650 | 7 |
_aEpigenetics. _2fast _0(OCoLC)fst01893642 |
|
| 650 | 7 |
_aGenetic regulation. _2fast _0(OCoLC)fst00940086 |
|
| 653 | 0 | 0 | _a Biochemistry, |
| 653 | 0 | 0 | _aGenetics and Genomics, |
| 653 | 0 | 0 | _aMolecular and Cell Biology, |
| 653 | 0 | 0 | _aEvolutionary Biology |
| 856 | 4 | 0 |
_3https://academic.oup.com/book/26005 _uhttps://academic.oup.com/book/26005 _yClick here |
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