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008			180518s2010 xxu||||go|||| 00| 0 eng d
020			_a9780198569237 ( e-book )
040			_aMAIN _beng _cIN-MiVU
041	0		_aeng
100	1		_a Vijg, Jan
245	0	0	_aAging of the Genome : _bThe dual role of DNA in life and death [ electronic resource ] / _cby Jan Vijg.
260			_bOxford Scholarship Online , _c2010
520			_aAging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. This book critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides a synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.
650	1	0	_aGenetics and Molecular Biology
650	1	0	_aPhysiology
650	1	0	_aZoology
655		4	_aElectronic books
856	4	0	_uhttps://doi.org/10.1093/acprof:oso/9780198569237.001.0001 _yhttps://doi.org/10.1093/acprof:oso/9780198569237.001.0001 _zView to click
942			_2ddc _cEB