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IN-MiVU |
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20240626134337.0 |
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240626s2019 xxka gob 001 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9780191869266 |
| Terms of availability |
GBP258.75 |
| Qualifying information |
(e-book) |
| 024 7# - OTHER STANDARD IDENTIFIER |
|---|
| Source of number or code |
DOI: |
| Standard number or code |
https://doi.org/10.1093/oso/9780198831204.001.0001 |
| 040 ## - CATALOGING SOURCE |
|---|
| Language of cataloging |
eng |
| Transcribing agency |
IN-MiVU |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Edition number |
21 |
| Classification number |
572.865 |
| Item number |
LUC/E |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Lucchesi, J. C. |
| Relator term |
author |
| Fuller form of name |
(John C.) |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Epigenetics, nuclear organization and gene function : |
| Remainder of title |
With implications of epigenetic regulation and genetic architecture for human development and health / |
| Statement of responsibility, etc. |
by John C. Lucchesi. |
| Medium |
[electronic resource] |
| 250 ## - EDITION STATEMENT |
|---|
| Edition statement |
First edition. |
| 260 3# - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Oxford, United Kingdom : |
| Name of publisher, distributor, etc. |
Oxford University Press, |
| Date of publication, distribution, etc. |
2019. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
e-book contains 286 pages; |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Includes bibliographical references and index. |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Contents<br/>Front Matter<br/>Copyright Page <br/>Dedication and Acknowledgments <br/>About the Author <br/>Preface <br/>Part I An Introduction to Epigenetics and Epigenetic Regulation<br/>John C. Lucchesi<br/>Expand1 Epigenetic phenomena in fungi, plants and animals <br/>View chapter<br/>Expand2 The basic structure of chromatin <br/>View chapter<br/>Expand3 The basic mechanism of gene transcription <br/>View chapter<br/>Part II Transcription is Regulated by Epigenetic Mechanisms<br/>John C. Lucchesi<br/>Expand4 Chromatin modification and remodeling <br/>View chapter<br/>Expand5 Epigenetic chromatin changes and the transcription cycle <br/>View chapter<br/>Expand6 The role of non-coding RNAs <br/>View chapter<br/>Expand7 Maintenance of the active and inactive states <br/>View chapter<br/>Expand8 DNA methylation and gene expression <br/>View chapter<br/>Expand9 Regulation of domains and whole chromosomes <br/>View chapter<br/>Part III The Interplay Between Transcription and Nuclear Structures<br/>John C. Lucchesi<br/>View part front matter <br/>Expand10 Architectural organization of the genome <br/>View chapter<br/>Expand11 The nuclear envelope <br/>View chapter<br/>Expand12 The nucleolus <br/>View chapter<br/>Expand13 Nuclear bodies <br/>View chapter<br/>Part IV Inheritance of Chromatin Structure and Functional States<br/>John C. Lucchesi<br/>Expand14 Chromatin replication <br/>View chapter<br/>Expand15 DNA repair and genomic stability <br/>View chapter<br/>Expand16 Inheritance of chromatin modifications through the cell cycle <br/>View chapter<br/>Expand17 Stem cells <br/>View chapter<br/>Expand18 Nuclear reprogramming and induced pluripotency <br/>View chapter<br/>Expand19 Transgenerational inheritance of epigenetic traits <br/>View chapter<br/>Part V Epigenetics, Human Health and Development<br/>John C. Lucchesi<br/>View part front matter <br/>Expand20 Aging, cellular senescence and cancer: the role of genomic instability, cellular homeostasis and telomeres <br/>View chapter<br/>Expand21 Aging, cellular senescence and cancer: epigenetic alterations and nuclear remodeling <br/>View chapter<br/>Expand22 Developmental systems and their dysfunction <br/>View chapter<br/>End Matter<br/>Index |
| 520 3# - SUMMARY, ETC. |
|---|
| Summary, etc. |
Abstract<br/>Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. Epigenetic changes, consisting principally of DNA methylation, histone modifications and non-coding RNAs, maintain and modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. This book’s primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and its interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin) and its distribution within a functionally compartmentalized nucleus. Dysfunctions at any level of genetic regulation have the potential to result in an increased susceptibility to disease or actually give rise to overt pathologies. As illustrated in this book, research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Epigenetics. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Genetic regulation. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Epigenomics. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Epigenetics. |
| Source of heading or term |
fast |
| Authority record control number or standard number |
(OCoLC)fst01893642 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Genetic regulation. |
| Source of heading or term |
fast |
| Authority record control number or standard number |
(OCoLC)fst00940086 |
| 653 00 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Biochemistry, |
| 653 00 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Genetics and Genomics, |
| 653 00 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Molecular and Cell Biology, |
| 653 00 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Evolutionary Biology |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
|---|
| Materials specified |
https://academic.oup.com/book/26005 |
| Uniform Resource Identifier |
<a href="https://academic.oup.com/book/26005">https://academic.oup.com/book/26005</a> |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
E-Book |
